<p><p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">型号：LSI MVC1000</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">OCTA活体动物三维微循环成像系统世界上唯一可以在活体上可视化毛细血管及量化流速的微米级三维成像设备。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">功能简述</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">血管微循环活体监测系统是一种能以微米分辨率无创获取生物组织微血管形态的三维可视化的成像技术，该系统具有很高的空间分辨率，能观察到单根毛细血管，如活体大脑微血管、视网膜微血管、肿瘤周围处微血管、皮肤微血管、心脏微血管等都可以得到较高分辨率的高清3D成像。设备无需特殊标记，非接触性检测，超广角视野范围，超高速的扫描，都使得更好、更快的获得组织的高清三维微血管结构成像。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:center"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"><img src="https://msimg.bioon.com/bionline/ewebeditor/uploadfile/202303/20230321113503455.jpg" style="height:259px; width:383px"></span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">原理特点</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:center"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493107.png" style="height:217px; width:540px"></span></span></strong><span style="background-color:#ffffff"><span style="color:#404040">OCTA血流识别原理</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:center"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">优 势：</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">高分辨率：达微米级，具有1-3mm穿透深度，可进行在体的三维组织成像；</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">无标记：无需造影剂的三维高分辨率微血管成像，可监测多种血管相关疾病模型</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">的病理改变；</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">速度快：可实现达350fps的快速断层扫描；</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">应用广泛：可对多种组织及器官进行微血管成像如脑组织，皮肤，骨（颅骨，股 骨髁，周围软组织等），内脏（肝，肾，子宫，肠等），肿瘤等；并且可适用于 多种动物模型如人，大小鼠，斑马鱼，鹌鹑蛋等；</span></span><img alt="" src="file:///C:\Users\coocaa\AppData\Local\Temp\ksohtml\wps27B4.tmp.png" style="height:32px; width:32px"></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">皮肤微血管成像</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:12pt"><span style="background-color:#ffffff"><strong><span style="font-size:13.5000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493108.png" style="height:263px; width:540px"></span></span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><strong><span style="background-color:#ffffff"><span style="color:#404040">成像效果</span></span></strong></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:18pt"><span style="background-color:#ffffff"><strong><strong><span style="font-size:13.5000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493109.png" style="height:541px; width:540px"></span></span></span></strong></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">评价指标 : </span></span></strong><strong><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></strong><span style="background-color:#ffffff"><span style="color:#404040">血管形态，长度，密度，灌注面积以及孔隙率</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">血管微循环监测系统可对成像结果进行血管形态，血管网络密度和血流灌注量等指标</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">进行量化评估，给予血管网络病理生理变化的全面记录。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">高分辨率成像效果</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:12pt"><span style="background-color:#ffffff"><strong><span style="font-size:13.5000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493110.png" style="height:565px; width:540px"></span></span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">研究实力</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">1. 微循环成像研究年龄相关的毛细血管密度损失</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:12pt"><span style="background-color:#ffffff"><strong><span style="font-size:12.0000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493111.png" style="height:474px; width:540px"></span></span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">利用微循环监测系 统对幼鼠和老年鼠 进行的脑部微血管 成像来探究年龄因 素对脑血管微循环 的影响， 白光照片 并未发现明显差异， 而OCTA微循环成像 可以看到幼年鼠脑 部微血管分布均匀， 老年鼠在红色箭头 位置微血管分布明 显降低， 血管密度 量化结果也表明老年鼠的微血管密度 明显降低。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">2.微循环成像研究不同皮肤状态的微血管形态</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:12pt"><span style="background-color:#ffffff"><strong><span style="font-size:12.0000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493112.png" style="height:397px; width:540px"></span></span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">图（A）常见蓝色痣的照片。（B）是（A）的外表面微血管图像。（C）和（D）分别对应（B）中部和下部区 域的OCT断层扫描图像。（E）正常痣的照片。（F）是（E）的外表面微血管图像。（G）和（H）分别对应于（F）的中部和下部区域的OCT扫描。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">使用微循环系统监测不同皮肤状态下的微血管结构及 形态，结果表明不同皮肤状态下的微血管形态显著不 同，断层扫描图像也显示了皮肤结构的差异。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:16px"><strong><span style="background-color:#ffffff"><span style="color:#404040">3. 微循环成像用来评估心脏补片的血管生成</span></span></strong></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:10.5pt"><strong><span style="font-size:12.0000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493114.png" style="height:509px; width:540px"></span></span></span></strong></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">a）为三维立体重建图像；（b）为定量分析测定区域灌注血管的密度 （红色为健康区域血管密度,蓝色为有 移植物的区域）；（c）为测定SA和 μV+SA移植物的容积灌注率。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">通过胚胎干细胞衍生的内皮细胞形成微 血管网络并植入到梗死大鼠的心脏组织 中，采用微血管成像技术来评估血管化 和有效的灌注情况，植入5天后发现具有 人工微血管结构辅助明显高于内皮细胞 自由生长的血管灌注情况。微血管成像 技术对新生血管组织的血管化以及有效 灌注是一个非常有效的观察手段。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">4. 微循环成像对脑缺血模型进行纵向研究的观察</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:12pt"><span style="background-color:#ffffff"><strong><span style="font-size:12.0000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493115.png" style="height:513px; width:540px"></span></span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">我们在MCAO (0 ~ 90min)中从50min开始每隔 10 m i n 进 行 一 次 微 血 管 网 络 成 像 采 集， 90min进行再灌注。绿色区域表示在闭塞期间MCA区域缺乏血流。白色箭头表示是MCAO后24 小 时 血 管 重 构 发 生 的 区 域 。 图 像 大 小 为2.2×4.4 mm2。右下方的图像是50分钟时拍摄 的血管网络图覆盖在24小时后的梗死组织区域。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">同一小鼠同一位置脑部缺血及再灌注模型清 晰的微血管灌注及重构活体跟踪。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:16px"><strong><span style="background-color:#ffffff"><span style="color:#404040">5. 微循环成像用于MCAO模型的糖尿病鼠脑部疾病的研究</span></span></strong></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:10.5pt"><strong><span style="font-size:12.0000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493116.png" style="height:345px; width:540px"></span></span></span></strong></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">微循环系统监测db/+和db/db模型鼠脑缺血再灌注后24h过程中的脑部ACA和MCA区域微循环变化，图 中血流方向用彩色编码。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">评估糖尿病模型动物的脑缺血后再灌注的血流恢复情况，采用微循环系统纵向观察模型缺血前及缺血后 再灌注及灌注24h后的脑部ACA/MCA处的血流情况，结果表明具有糖尿病的模型鼠再灌注后的血流恢复 情况显著低于对照组。提示糖尿病可能是影响脑侧支再灌注损伤加剧的原因。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">6. 肿瘤及其他新生血管监测等相关研究</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:12pt"><span style="background-color:#ffffff"><strong><span style="font-size:12.0000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493117.png" style="height:202px; width:540px"></span></span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040">高精度无需标记的微血管 成像监测系统适用于血管 生成的长期观察。</span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:justify"><span style="font-size:16px"><span style="background-color:#ffffff"><span style="background-color:#ffffff"><span style="color:#404040"> </span></span></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><span style="background-color:#ffffff"><strong><span style="background-color:#ffffff"><span style="color:#404040">大视野微血管成像展示</span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:12pt"><span style="background-color:#ffffff"><strong><span style="font-size:12.0000pt"><span style="background-color:#ffffff"><span style="color:#404040"><img alt="" src="https://nwzimg.wezhan.cn/contents/sitefiles2053/10267688https://msimg.bioon.com/bionline//images/28493118.png" style="height:284px; width:540px"></span></span></span></strong></span></span></p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"> </p> <p style="margin-left:0pt; margin-right:0pt; text-align:left"><span style="font-size:16px"><strong><span style="background-color:#ffffff"><span style="color:#404040">血管微循环血流监测测试服务</span></span></strong></span></p> <p style="margin-left:0pt; 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