PCBP1 Mouse Monoclonal Antibody [Clone ID: LBI10B7]
产品名称: PCBP1 Mouse Monoclonal Antibody [Clone ID: LBI10B7]
英文名称: PCBP1 Mouse Monoclonal Antibody [Clone ID: LBI10B7]
产品编号: AMM17296V
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: WB 1:2000
安诺伦(北京)生物科技有限公司
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别名:HEL-S-85; hnRNP-E1; hnRNP-X; HNRPE1; HNRPX 产品概述:PCBP1 mouse monoclonal antibody, clone LBI10B7 总结:This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]