ATF7 Rabbit pAb (APR30257N)
产品名称: ATF7 Rabbit pAb (APR30257N)
英文名称: ATF7 Rabbit pAb (APR30257N)
产品编号: APR30257N
产品价格: null
产品产地: 美国
品牌商标: Leading Biology
更新时间: null
使用范围: WB (HepG2)
安诺伦(北京)生物科技有限公司
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分子量:Calculated MW: 13kDa/33kDa/49kDa/50kDa/51kDa/52kDa Observed MW: 53kDa 细胞定位:Cytoplasm, Nucleus, nucleoplasm 稀释方法:WB 1:500 - 1:2000 IF 1:50 - 1:200 总结:Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes (By similarity. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation (By similarity. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair (By similarity.