产品概述：Purified recombinant protein of Human collagen, type XXV, alpha 1 (COL25A1), transcript variant 1, Lys573-Gln653, with N-terminal His-ABP tag, expressed in E.coli, 50ug

蛋白长度：A DNA sequence encoding the region(Lys573-Gln653) of COL25A1

表达系统：E. coli

种属：Human

标签类型：N-His ABP

分子量：23.5 kDa

通用名：COL25A1

总结：This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

形式：Liquid

浓度：>50 ug/mL as determined by microplate BCA method

纯度：> 80% as determined by SDS-PAGE and Coomassie blue staining

储存溶液：50mM Tris, pH8.0, 8M Urea

别名：AMY; CFEOM5; CLAC; CLAC-P; CLACP