LDLR polyclonal antibody
产品名称： LDLR polyclonal antibody
英文名称： LDLR polyclonal antibody
产品编号： PAB15520
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of LDLR.
- Immunogen:
- A synthetic peptide corresponding to amino acids 500-550 of human LDLR.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Primates
- Specificity:
- This is specific to both the unglycosylated and glycosylated forms of the LDL Receptor. Immunogen has 100% homology with monkey and 92% homology with mouse. This antibody is useful for Western blot, where bands are seen ~95 KDa and ~160 KDa representing the unglycosylated and glycosylated forms of the LDL receptor, respectively.
- Form:
- Liquid
- Storage Buffer:
- In PBS (30% glycerol, 0.1% sodium azide)
- Storage Instruction:
- Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (0.5 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor.
Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX.Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12766-71.
- 2.
- The low density lipoprotein receptor. Identification of amino acids in cytoplasmic domain required for rapid endocytosis.
Davis CG, van Driel IR, Russell DW, Brown MS, Goldstein JL.J Biol Chem. 1987 Mar 25;262(9):4075-82.
- Entrez GeneID:
- 3949
- Protein Accession#:
- P01130
- Gene Name:
- LDLR
- Gene Alias:
- FH,FHC
- Gene Description:
- low density lipoprotein receptor
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
- Other Designations:
- LDL receptor,low-density lipoprotein receptor class A domain-containing protein 3
- Gene Pathway
- Related Disease
- Alzheimer Disease
- Alzheimer disease
- Amyotrophic Lateral Sclerosis
- Amyotrophic lateral sclerosis
- Anemia, Sickle Cell
- Anemia, sickle cell
- Aortic Diseases
- Arteriosclerosis
- Atherosclerosis
- Atherosclerosis
- Biliary Tract Neoplasms
- Bone Diseases, Metabolic
- Brain Infarction
- Brain Ischemia
- Calcinosis
- Cardiovascular Diseases
- Carotid Artery Diseases
- Cellulitis
- Cerebral Infarction