重组人白细胞介素-7受体a（CD127）蛋白
| 英文名称 | Recombinant human IL-7R Alpha / CD127 protein, His (HEK293) |
| 中文名称 | 重组人白细胞介素-7受体a（CD127）蛋白 |
| 别 名 | Interleukin-7 receptor subunit alpha; IL7R; CD 127; CD127; CD127 antigen; CDW127; IL 7R alpha; IL 7R; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; IL7RA; IL7Ralpha; ILRA; Interleukin 7 receptor alpha chain; Interleukin 7 receptor; Interleukin 7 receptor isoform H5 6; IL7RA_HUMAN; Recombinant human IL-7R Alpha / CD127 protein, His (HEK293) |
| 理论分子量 | 29.3kDa |
| 检测分子量 | 40-70 kDa |
| 性 状 | Liquid |
| 浓 度 | ＞0.5 mg/ml |
| 物 种 | Human |
| 序 列 | 21-239/459 |
| 纯 度 | >95% as determined by SDS-PAGE |
| 纯化方法 | AC |
| 内毒素 | Not analyzed |
| 表达系统 | HEK293 cell |
| 活性 | Yes |
| 标签 | His |
| 缓 冲 液 | PBS (pH=7.4) |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 | The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). |